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What Kills Cold Sores Instantly?

This article is a part of our Q&A series in which we give detailed answers to our readers' questions. Have a question? Don't hesitate and send it to us to get a detailed answer!

Cold sores, also known as fever blisters, are small, fluid-filled blisters that appear around the lips or inside the mouth. They are caused by the herpes simplex virus (HSV-1) and can be painful and unsightly. While there is no cure for the virus that causes cold sores, there are treatments that can help to alleviate the symptoms and speed up the healing process.

What are Cold Sores?

Cold sores are the result of an infection with the herpes simplex virus. This virus is highly contagious and can be spread through close personal contact, sharing utensils, or even through the air. Cold sore outbreaks may be triggered by various factors such as stress, fatigue, hormonal changes, or a weakened immune system.

Available Treatment Options

While it is virtually impossible to instantly eliminate cold sores once they appear, various treatments can significantly reduce their lifespan and alleviate discomfort.
Here are some options:

1. Antiviral Medications

Antiviral medications are one of the most effective treatments for cold sores. They don’t kill the virus but they can inhibit its reproduction.

  • Acyclovir (Zovirax): This is available as a cream or an oral medication. It is most effective when used at the first sign of a cold sore.
  • Valacyclovir (Valtrex): This is an oral medication that can reduce the severity of cold sores and shorten the duration of an outbreak.
  • Famciclovir (Famvir): Another oral antiviral medication similar to Valacyclovir.

2. Topical Treatments

There are also topical treatments that can be applied directly to the cold sore.

  • Penciclovir (Denavir): This is a cream that can be applied to the cold sore to shorten the duration of the outbreak.
  • Docosanol (Abreva): This over-the-counter cream can be effective if applied early on in the outbreak.

3. Home Remedies and Alternative Treatments

There are also various home remedies and alternative treatments that can provide relief.

  • Cold Compresses: Applying a cold compress to the cold sore can help to reduce inflammation and relieve pain.
  • Lysine: Some studies have suggested that lysine, an essential amino acid, can help to treat or prevent cold sore outbreaks.
  • Lemon Balm: Lemon balm is believed to have antiviral properties, and creams that contain lemon balm are thought to help cold sores heal more quickly.
  • Tea Tree Oil: This essential oil has antiviral and antibacterial properties, and can be applied diluted to the cold sore with a cotton swab.


While treating cold sores, it is important to avoid spreading the virus to other people or other parts of your own body.

  • Avoid touching the cold sore
  • Wash your hands frequently
  • Avoid sharing utensils, lip balm, or anything else that may come into contact with the cold sore
  • Avoid close contact with others, especially newborns, pregnant women, or anyone with a weakened immune system

Bottom Line

Cold sores can be bothersome, but there are various treatments available that can help to reduce the severity and duration of an outbreak. Although there is no treatment that can truly kill a cold sore instantly, acting swiftly at the first sign of a cold sore and employing a combination of antiviral medications, topical treatments, and home remedies can greatly lessen symptoms and accelerate the healing process. Additionally, exercising caution to prevent the spread of the virus is critical. If you frequently suffer from cold sores or experience severe or unusually long-lasting outbreaks, it’s recommended to consult a healthcare provider for a tailored treatment plan.

This Q&A series article is complete and was published on July 18, 2023, and last updated on July 18, 2023.

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