Key Facts Both hydroxyapatite and fluoride are substances used in toothpastes to protect and repair teeth. Fluoride works by strengthening tooth enamel and making it more resistant to acid erosion and decay. Hydroxyapatite contributes to the remineralization of tooth enamel, promoting repair and protection. Hydroxyapatite is the main mineral component of tooth enamel, while fluoride is not naturally occurring in teeth. Both hydroxyapatite and fluoride toothpastes have been shown to be effective in preventing dental caries (cavities). How Does Fluoride Toothpaste Work? Fluoride in toothpaste works to protect teeth in two key ways. First, it slows down the process of demineralization – the dissolution of tooth enamel caused by acids…